Using the cell’s own mechanism for death is a highly effective method. Additionally, targeting apoptosis is the most successful non-surgical treatment . Targeting apoptosis is also effective for all types of cancer, as apoptosis evasion is a hallmark of cancer and is nonspecific to the cause or type of the cancer.
Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies .
Like a double-edged sword, every defect or abnormality along the apoptotic pathways may also be an interesting target of cancer treatment. Drugs or treatment strategies that can restore the apoptotic signalling pathways towards normality have the potential to eliminate cancer cells, which depend on these defects to stay alive .
Introduction Cell death, particularly apoptosis, is probably one of the most widely-studied subjects among cell biologists. Understanding apoptosis in disease conditions is very important as it not only gives insights into the pathogenesis of a disease but may also leaves clues on how the disease can be treated.
How does targeted cancer therapy work?
Cancer cells grow and proliferate endlessly. Targeted therapy to stimulate cell death or “apoptosis” can help keep tumors in check. Targeted cancer therapy is a focused treatment for certain cancers in which the specific cancer -causing factors can be identified and targeted with drugs .
What is a ribosome inhibitor?
Ribosome inhibitors are among the most successful antimicrobial drugs and constitute more than half of all medicines used to treat infections. However, bacterial infections are becoming increasingly difficult to treat because the microbes have developed resistance to the most effective antibiotics, creating a major public health care threat.
While we were reading we ran into the question “What are ribosome-targeting antibiotics?”.
The majority of ribosome-targeting antibiotics in clinical trials are semi-synthetic derivatives of naturally produced compounds , but further work will be required to develop antibiotics that target novel sites on the ribosome. The ribosome is one of the main antibiotic targets in the bacterial cell.
Ribosomes of pathogenic bacteria are major targets for antibiotics. Ribosomes are a cellular organelle catalysing the translation of genetic code into proteins. They are protein/RNA assemblies arranged in two subunits that associate for performing protein biosynthesis.
You may be wondering “How do drugs affect ribosomes?”
Drugs inhibit ribosome function either by interfering in messenger RNA translation or by blocking the formation of peptide bonds at the peptidyl transferase centre. These effects are the consequence of the binding of drugs to the ribosomal subunits.
One of the next things we wondered was: is the bacterial ribosome a target for antibiotics?
The bacterial ribosome as a target for antibiotics. Wilson, D. N. The A-Z of bacterial translation inhibitors.
Does targeted weight loss work for belly fat?
Targeted weight loss is a bust when it comes to work outs , however, working out reduces total body fat, including your belly . The belly is often the hardest fat to remove because it is where fat likes to be stored.
Some studies suggest that the soluble fiber in blueberries—and oatmeal —may specifically target belly fat. In one study of rats at the University of Michigan Cardiovascular Center, those that were given blueberries lost more belly fat while dieting than those who lost weight without the berries, says Science Daily.
Another thing we wondered was; what is the best way to lose belly fat?
Weight training and cardiovascular exercise will reduce fat across the body. Aerobic exercise — like walking, running, and swimming — can allow major reductions in abdominal fat ( 32, 33 ).
Are there any supplements that reduce belly fat?
We dug into the research to find supplements that actually have evidence in reducing body fat and more specifically, supplements that reduce belly fat. Our findings led us to create a powerful fat burner that contained the most evidence backed ingredients at clinically tested dosages.
One more inquiry we ran across in our research was “What’s behind belly fat?”.
What ‘s behind belly fat. This is likely due to a decreasing level of estrogen, which appears to influence where fat is distributed in the body. The tendency to gain or carry weight around the waist — and have an “apple” rather than a “pear” shape — might have a genetic component as well.